Fecal Microbiota Transplantation

Fecal Transplantation

Dayton Gastroenterology is proud to work with OpenBiome for fecal microbiota transplantation (FMT) in order to help people reconstitute their gut bacteria. OpenBiome is a nonprofit stool bank and research platform that works to make fecal transplant safe and affordable for patients suffering from recurrent C. difficile. OpenBiome also researches FMT's role in treating other gastrointestinal diseases.

Fecal Transplant is a relatively new treatment that is over 90% effective in treating recurrent C. difficile infections in patients that have failed to recover using antibiotics.

Fecal Microbial Transplantation uses a fecal preparation from carefully screened, healthy stool donors. The donated preparation is transplanted into the colon of the patient through one of multiple routes: colonoscopy, naso-enteric tube, or capsules.

Reasons for the Exam & Benefits

It is thought that fecal transplants work by repopulating the patient's microbiome with diverse microorganisms that competitively exclude C. difficile. By recreating a healthy gut community, C. difficile is out-competed by the many other different bacterial species. If a patient doesn't respond to antibiotic treatment for C. difficile, as C. difficile can form spores that are resistant to antibiotics, the antibiotic has disrupted the ecosystem by killing the protective bacteria. Once the C. difficile pathogen establishes itself in the patient's gut, it produces toxins that cause severe diarrhea, abdominal pain, and fever. By utilizing fecal transplant, an infusion of healthy bacteria out-competes the C. difficile.

Fecal microbiota transplantation is also being researched to treat other gastrointestinal disease, such as Irritable Bowel Syndrome (IBS) and Crohn's Disease.

Risks and Side Effects

FMT is a powerful tool for treating C. difficile infection, but there are also some risks involved with the procedure. Stool donors are carefully screened for known infections agents prior to donation, but there is always a risk that the tests may fail to detect a pathogen. There can also be procedural risks associated with receiving FMT by colonoscopy or other administration methods.

Dayton Gastroenterology, Inc.

  • Beavercreek (Sylvania) Office & Endoscopy Center - 75 Sylvania Drive, Beavercreek, OH 45440 Phone: 937-320-5050 Fax: 937-320-5060
  • Beavercreek (Indian Ripple) Office & Endoscopy Center - 4200 Indian Ripple Road, Beavercreek, OH 45440 Phone: 937-320-5050 Fax: 937-320-5060
  • Englewood Office & Endoscopy Center - 9000 N. Main Street Suite 405, Englewood, OH 45415 Phone: 937-320-5050 Fax: 937-320-5060
  • Miamisburg Office - 415 Byers Road Suite 100, Miamisburg, OH 45342 Phone: 937-320-5050 Fax: 937-320-5060

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